Y, the Last Man. Vol. 1. Unmanned

"In the summer of 2002, a plague of unknown origin destroyed every last sperm, fetus, and fully developed mammal with a Y chromosome, with the apparent exception of one young man ... Now, aided by the mysterious Agent 355, the human male Yorick Brown must contend with dangerous extremists, a hoped-for reunion with a girlfriend on the other side of the globe, and the search for exactly why he's the only man to survive."--Book 1, Back cover.